Qualitative and quantitative distribution of plasminogen activators in organs from healthy adult mice

Twenty organs from healthy adult mice were tested for plasminogen activator activity. All were positive although specific activities varied 200-fold. Tissues with high activity were lung, uterus, brain and kidney. Endocrine glands were moderately rich in activator activity, and lymphoid tissues were...

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Bibliographic Details
Published in:FEBS letters 1986, Vol.194 (1), p.96-100
Main Authors: Danglot, Giséle, Vinson, Denise, Chapeville, François
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Brain Chemistry
Electrophoresis, Polyacrylamide Gel
Endocrine Glands - analysis
Enzymes and enzyme inhibitors
Female
Fundamental and applied biological sciences. Psychology
Hydrolases
Kidney - analysis
Lung - analysis
Male
Mice
Mice, Inbred BALB C
Plasminogen activator Electrophoresis (Mouse organ)
Plasminogen Activators - analysis
Uterus - analysis
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Summary:Twenty organs from healthy adult mice were tested for plasminogen activator activity. All were positive although specific activities varied 200-fold. Tissues with high activity were lung, uterus, brain and kidney. Endocrine glands were moderately rich in activator activity, and lymphoid tissues were poor. Molecular mass characterization was carried out. Two enzymatic forms were observed in all twenty organs: a 70 kDa form similar to human tissue plasminogen activator and a 48 kDa form analogous to mouse urokinase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(86)80058-8