Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma

We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting 99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 1...

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Bibliographic Details
Published in:Annals of nuclear medicine 1994-06, Vol.8 (2), p.139-145
Main Authors: Hasegawa, Y, Nakano, S, Sobue, T, Fujita, M, Ishiguro, S, Sasaki, Y, Imaoka, S, Tanaka, S, Kasugai, H, Inoue, A
Format: Article
Language:English
Subjects:
Age Factors
alpha-Fetoproteins - analysis
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - epidemiology
Female
Humans
Liver - diagnostic imaging
Liver - pathology
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - epidemiology
Logistic Models
Male
Middle Aged
Organotechnetium Compounds
Radionuclide Imaging
Sex Factors
Tryptophan - analogs & derivatives
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Summary:We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting 99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 12.1 times higher in patients with a tumor diameter of 5.0-7.9 cm than in those with a tumor diameter of 2.0-5.0 cm. Among the other variables, the serum AFP level and sex were suggested to have effects similar to those of the tumor size on Tc-99m PMT uptake by HCC. The grade of morphological differentiation of the tumor was therefore most markedly related to Tc-99m PMT uptake.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03165019