Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma

• Published in: Annals of nuclear medicine 1994-06, Vol.8 (2), p.139-145
• Main Authors: Hasegawa, Y, Nakano, S, Sobue, T, Fujita, M, Ishiguro, S, Sasaki, Y, Imaoka, S, Tanaka, S, Kasugai, H, Inoue, A
• Format: Article
• Language: English
• Subjects: Age Factors; alpha-Fetoproteins - analysis; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - epidemiology; Female; Humans; Liver - diagnostic imaging; Liver - pathology; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - epidemiology; Logistic Models; Male; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Sex Factors; Tryptophan - analogs & derivatives
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/BF03165019

We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting 99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 12.1 times higher in patients with a tumor diameter of 5.0-7.9 cm than in those with a tumor diameter of 2.0-5.0 cm. Among the other variables, the serum AFP level and sex were suggested to have effects similar to those of the tumor size on Tc-99m PMT uptake by HCC. The grade of morphological differentiation of the tumor was therefore most markedly related to Tc-99m PMT uptake.