fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection

Several acute transforming retroviruses encode tyrosine-specific protein kinases which possess structural and functional relationships to cell-surface receptors for certain growth factors 1,2 . One such tyrosine kinase is encoded by the onc gene, v- fgr , of Gardner-Rasheed feline sarcoma virus (GR-...

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Bibliographic Details
Published in:Nature (London) 1986-01, Vol.319 (6050), p.238-240
Main Authors: Cheah, Marc S. C, Ley, Timothy J, Tronick, Steven R, Robbins, Keith C
Format: Article
Language:English
Subjects:
B-Lymphocytes
Biological and medical sciences
Burkitt Lymphoma - genetics
Cell Line
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Disease
Epstein-Barr virus
Fundamental and applied biological sciences. Psychology
Genetics
Growth factors
Herpesvirus 4, Human - genetics
Humanities and Social Sciences
Humans
letter
Lymphocytes
Lymphoma
Medical research
Molecular and cellular biology
multidisciplinary
Proto-Oncogenes
RNA, Messenger
Sarcoma
Science
Science (multidisciplinary)
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Summary:Several acute transforming retroviruses encode tyrosine-specific protein kinases which possess structural and functional relationships to cell-surface receptors for certain growth factors 1,2 . One such tyrosine kinase is encoded by the onc gene, v- fgr , of Gardner-Rasheed feline sarcoma virus (GR-FeSV) 3–6 . Recently, we have isolated and characterized the human gene, c- fgr , corresponding to the viral onc sequence and have shown that c- fgr is a unique gene located on the short arm of chromosome 1 (ref. 7). Here we report that certain lymphomas (but not sarcomas or carcinomas) express fgr -related messenger RNA. This transcript is detected in Burkitt's lymphoma cell lines naturally infected with Epstein-Barr virus (EBV), but not in EBV-negative Burkitt's lymphoma cells. Normal umbilical cord or peripheral blood lymphocyte lines established in vitro by EBV infection also contain detectable c- fgr mRNA. Moreover, a 50-fold increase of the steady-state c- fgr mRNA concentration is observed when uninfected Burkitt's lymphoma cell lines are deliberately infected with EBV. These findings demonstrate for the first time the induction of a proto-oncogene in response to infection by a DNA tumour virus.
ISSN:0028-0836
1476-4687
DOI:10.1038/319238a0