Hepatitis B Virus DNA in Hepatitis B Surface Antigen-Positive Blood Donors: Relation to the Hepatitis B e System and Outcome in Recipients

The presence of hepatitis B virus (HBV) DNA was investigated in 26 hepatitis B surface antigen-positive blood donors. Three donors (12%) were concordantly positive for HBV DNA and hepatitis B e antigen (HBeAg) and had IgM antibody to hepatitis B core antigen (anti-HBc). Two donors (8%) had HBV DNA w...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-02, Vol.153 (2), p.298-303
Main Authors: Krogsgaard, Kim, Wantzin, Per, Aldershvile, Jan, Kryger, Peter, Andersson, Poul, Nielsen, Jens Ole
Format: Article
Language:English
Subjects:
Adolescent
Aged
Biological and medical sciences
Blood
Blood donation
Blood Donors
Blood transfusion
Carrier State
Child
DNA, Viral - analysis
Female
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B - immunology
Hepatitis B - microbiology
Hepatitis B - transmission
Hepatitis B Antibodies - analysis
Hepatitis B Antigens - analysis
Hepatitis B Core Antigens - immunology
Hepatitis B e Antigens - analysis
Hepatitis B e Antigens - immunology
Hepatitis B Surface Antigens - analysis
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - physiology
Human viral diseases
Humans
Immunoglobulin M - analysis
Infant
Infections
Infectious diseases
Liver
Male
Medical sciences
Middle Aged
Original Articles
Symptoms
Viral diseases
Viral hepatitis
Virus Replication
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Summary:The presence of hepatitis B virus (HBV) DNA was investigated in 26 hepatitis B surface antigen-positive blood donors. Three donors (12%) were concordantly positive for HBV DNA and hepatitis B e antigen (HBeAg) and had IgM antibody to hepatitis B core antigen (anti-HBc). Two donors (8%) had HBV DNA without HBeAg; both were positive for antibody to HBeAg and lacked IgM anti-HBc. Twenty-oneHBV DNA-negative donors had antibody to HBeAg, and all were negative for HBeAg and IgM anti-HBc. Blood units from 16 donors were transfused. A sufficient serological and clinical follow-up was available for 10HBV-susceptible recipients. Three recipients of HBV DNA-positive blood units were infected irrespective of HBeAg status or presence of IgM anti-HBc. Six (86%) of seven recipients of HBV DNA-negative blood units developed HBV infection. Thus all hepatitis B surface antigen-positive blood donors should still be considered infectious irrespective of status with regard to HBeAg, HBV DNA, and IgM anti-HBc.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/153.2.298