An Analysis of Coupled Multicomponent Diffusion in Interstitial Tissue

A one-dimensional multicomponent kinetic model was developed to simulate the interstitial diffusion of macromolecules in a three component system, consisting of water, the macromolecule and the interstitial matrix. Movement of the individual components was modeled as occurring in finite jumps betwee...

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Bibliographic Details
Published in:Journal of biomechanical engineering 1994-05, Vol.116 (2), p.164-171
Main Authors: Schreuders, P. D, Diller, K. R, Beaman, J. J, Paynter, H. M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dextrans - pharmacokinetics
Diffusion
Evaluation Studies as Topic
Extracellular Matrix - physiology
Fundamental and applied biological sciences. Psychology
General aspects
Kinetics
Macromolecular Substances
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
Models, Biological
Osmolar Concentration
Rabbits
Rheology
Sensitivity and Specificity
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Description
Summary:A one-dimensional multicomponent kinetic model was developed to simulate the interstitial diffusion of macromolecules in a three component system, consisting of water, the macromolecule and the interstitial matrix. Movement of the individual components was modeled as occurring in finite jumps between discrete low energy wells along paths defined in terms of species occupation. The flow rate was expressed as a function of the local species concentration, the jump distance, and a kinetic frequency parameter. The model, implemented in pseudo-bond graph form, was examined by fitting it to data obtained for the transport of fluorescein tagged dextran to determine the kinetic constants for that specific system.
ISSN:0148-0731
1528-8951
DOI:10.1115/1.2895715