Spatial structures in mitochondrial suspension induced by cation efflux

The formation of spatial structures in a thin unstirred layer of a mitochondrial suspension has been studied. It is shown that the structure formation depends on the state of the ion-transporting systems of mitochondria and that pattern development coincides with the activation of cation efflux from...

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Bibliographic Details
Published in:FEBS letters 1986-01, Vol.195 (1), p.339-343
Main Authors: Holmuhamedov, E.L., Evtodienko, Yu.V.
Format: Article
Language:English
Subjects:
(Rat liver mitochondria) Spatial structure Inhibitor effect
Animals
Biological and medical sciences
Calcium
Cations
Cell structures and functions
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
liver
mitochondria
Mitochondria - ultrastructure
Mitochondria and cell respiration
Molecular and cellular biology
Potassium
Strontium
Valinomycin - pharmacology
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Summary:The formation of spatial structures in a thin unstirred layer of a mitochondrial suspension has been studied. It is shown that the structure formation depends on the state of the ion-transporting systems of mitochondria and that pattern development coincides with the activation of cation efflux from preloaded mitochondria. Spatial structure formation is an energy-dependent process and is suppressed by respiratory chain inhibitors. Patterning is also inhibited by EGTA, EDTA and ruthenium red, reflecting the requirement for divalent cation translocation in mitochondria for the studied phenomenon.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(86)80189-2