Alterations in macrophage collagenase secretion induced by gold sodium thiomalate

The effects of gold sodium thiomalate (GST) on the production of specific collagenase by thioglycolateelicited macrophages was investigated. Our studies demonstrated that GST administration can significantly decrease collagenase production in a dose‐dependent manner. These effects were observed with...

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Bibliographic Details
Published in:Arthritis and rheumatism 1986-01, Vol.29 (1), p.75-81
Main Authors: Spalding, David M., Darby, Walter L., Heck, Louis W.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cattle
Cells, Cultured
Female
Gold Sodium Thiomalate - pharmacology
Humans
Macrophages - drug effects
Macrophages - enzymology
Medical sciences
Mice
Mice, Inbred Strains
Microbial Collagenase - metabolism
Muramidase - metabolism
Pharmacology. Drug treatments
Protein Biosynthesis
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Summary:The effects of gold sodium thiomalate (GST) on the production of specific collagenase by thioglycolateelicited macrophages was investigated. Our studies demonstrated that GST administration can significantly decrease collagenase production in a dose‐dependent manner. These effects were observed with levels of GST attainable in serum or synovial tissue during routine chrysotherapy. In addition, GST altered lysozyme secretion by activated macrophages in a pattern distinct from that of collagenase alteration. These effects of enzyme secretion were not secondary effects of GST on viability, general protein secretion, or the specific assay procedures utilized, and were not attributable to the thiomalate moiety. Thus, GST may exert its therapeutic effect in rheumatoid arthritis through interference with the production of degradative proteolytic enzymes, which are important effector molecules mediating tissue destruction.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780290110