Inhibition of angiogenesis as a strategy for tumor growth control

Angiogenesis is a complex sequence of events leading to the formation of new capillaries. Although essential to maturation and wound healing, most angiogenesis in the adult is associated with pathological events, such as the development of solid tumors. One approach to the inhibition of angiogenesis...

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Bibliographic Details
Published in:Molecular and chemical neuropathology 1994-02, Vol.21 (2-3), p.329-336
Main Authors: Herblin, W F, Gross, J L
Format: Article
Language:English
Subjects:
Animals
Antibodies - therapeutic use
Colonic Neoplasms - blood supply
Colonic Neoplasms - pathology
Colonic Neoplasms - therapy
Fibroblast Growth Factor 2 - antagonists & inhibitors
Fibroblast Growth Factor 2 - pharmacology
Fibroblast Growth Factor 2 - physiology
Humans
Mice
Mice, Nude
Neoplasms - blood supply
Neoplasms - pathology
Neoplasms - therapy
Neovascularization, Pathologic - prevention & control
Transplantation, Heterologous
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Summary:Angiogenesis is a complex sequence of events leading to the formation of new capillaries. Although essential to maturation and wound healing, most angiogenesis in the adult is associated with pathological events, such as the development of solid tumors. One approach to the inhibition of angiogenesis is the antagonism of basic fibroblast growth factor, a major angiogenic protein. Evidence is reviewed to suggest that inhibiting angiogenesis results in the suppression of tumor growth.
ISSN:1044-7393
DOI:10.1007/BF02815359