Expression of CD11/CD18 and ICAM-1 on monocytes and lymphocytes of HIV-1-infected individuals

The role of the leukocyte integrins in the infection of cells by HIV‐1 or in the progression of AIDS‐related disease is of continuing interest. Using a duallabeling flow cytometric method, we determined the level of expression of the leukocyte integrins and intercellular adhesion molecule 1 (ICAM‐1)...

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Bibliographic Details
Published in:Journal of leukocyte biology 1994-09, Vol.56 (3), p.304-309
Main Authors: Stent, Gianna, Cameron, Paul U., Crowe, Suzanne M.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - metabolism
Acquired Immunodeficiency Syndrome - pathology
Acquired Immunodeficiency Syndrome - physiopathology
AIDS/HIV
Antigens, CD - analysis
Antigens, CD - metabolism
Antigens, CD - physiology
CD11 Antigens
CD4
CD8 Antigens - analysis
CD8 Antigens - metabolism
CD8 Antigens - physiology
Cell Adhesion Molecules - analysis
Cell Adhesion Molecules - metabolism
Cell Adhesion Molecules - physiology
disease progression
dual labeling
Flow Cytometry
HIV-1 - isolation & purification
human immunodeficiency virus 1
Humans
Intercellular Adhesion Molecule-1
Monocytes - chemistry
Monocytes - microbiology
Monocytes - pathology
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Summary:The role of the leukocyte integrins in the infection of cells by HIV‐1 or in the progression of AIDS‐related disease is of continuing interest. Using a duallabeling flow cytometric method, we determined the level of expression of the leukocyte integrins and intercellular adhesion molecule 1 (ICAM‐1) on monocytes and lymphocytes from HIV‐1‐infected and uninfected individuals. The mean fluorescence of CD18 on lymphocytes and CD11c on monocytes of HIV‐1‐infected subjects was significantly higher than for the control group (P=.008 and.014, respectively). There was a trend toward higher fluorescence of CD11a on lymphocytes from HIV‐1‐infected subjects compared with cells from the control group (P=.089). Integrin expression on lymphocytes or monocytes from HIV‐infected individuals did not correlate with their CD4 lymphocyte number. However, the mean fluorescence associated with ICAM‐1 on monocytes and CD11a and CD18 expression on lymphocytes was related to clinical stage of disease. J. Leukoc. Biol. 56: 304–309; 1994.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.56.3.304