HALOTHANE—VERAPAMIL CAUSES REGIONAL MYOCARDIAL DYSFUNCTION IN THE DOG

Regional myocardial function was studied using sonomicrometry in six mongrel dogs, anaesthetized with halothane (1% inspired), as increasing doses of verapamil were given i. v. In addition to a gradual increase in end-diastolic length and a reduction in systolic shortening, an abnormal (paradoxical)...

Full description

Saved in:
Bibliographic Details
Published in:British journal of anaesthesia : BJA 1986-03, Vol.58 (3), p.321-326
Main Authors: RAMSAY, J.G., CUTFIELD, G.R., FRANCIS, C.M., DEVLIN, W.H., FOËX, D.P.
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Diastole - drug effects
Dogs
Halothane - pharmacology
Hemodynamics - drug effects
Medical sciences
Myocardial Contraction - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Systole - drug effects
Verapamil - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Regional myocardial function was studied using sonomicrometry in six mongrel dogs, anaesthetized with halothane (1% inspired), as increasing doses of verapamil were given i. v. In addition to a gradual increase in end-diastolic length and a reduction in systolic shortening, an abnormal (paradoxical) contraction pattern appeared in the apical region. This occured in the absence of coronary artery damage and at coronary perfusion pressures unlikely to result in ischaemia. Administration of verapamil in the presence of halothane results in regional dysfunction similar to that caused by the intracoronary administration of nifedipine
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.3.321