Background immunoglobulin-secreting cells specific for intestinal peptidoglycan-polysaccharides in mice

Natural antibodies to soluble peptidoglycan-polysaccharide complexes (PPC) from the human intestinal flora have been found in mammalian sera. In this study the occurrence and frequency of PPC-specific immunoglobulin-secreting cells (anti-PPC Ig-SC) were determined in lymphoid organs of normal (C57BL...

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Bibliographic Details
Published in:Immunobiology (1979) 1994-04, Vol.190 (3), p.295-301
Main Authors: van Helden-Meeuwsen, Cornelia G., Hazenberg, Maarten P.
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibody Formation - immunology
Antibody production
Antibody-Producing Cells - immunology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay - methods
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Immunoglobulin Isotypes - analysis
Intestines - immunology
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Polysaccharides - immunology
Proteoglycans - immunology
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Summary:Natural antibodies to soluble peptidoglycan-polysaccharide complexes (PPC) from the human intestinal flora have been found in mammalian sera. In this study the occurrence and frequency of PPC-specific immunoglobulin-secreting cells (anti-PPC Ig-SC) were determined in lymphoid organs of normal (C57BL × CBA)F1 mice. One out of 100 IgM-SC in the spleen and Peyer's patches was found to be specific for PPC. In the small intestine a small number of anti-PPC IgA-SC were present probably responsible for IgA secretion in the gut lumen since very low serum concentrations anti-PPC IgA were found. Anti-PPC IgG-SC were not detected, although some anti-PPC IgG was found in the serum. It is concluded that the spleen is the major lymphoid organ responsible for the production of natural antibodies to PPC.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(11)80277-9