Colocalization of growth hormone (GH) and glycoprotein subunit α in GH-producing pituitary adenomas in acromegalic patients

Thirty-one consecutive cases of pituitary adenoma in acromegalic patients were studied by immunohistochemistry. All adenomas contained cells immunoreactive with the anti-alpha-subunit of gonadotropic hormones (alpha; 0.6-53% of tumor cells) as well as with anti-growth hormone (GH; 4-74% of tumor cel...

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Bibliographic Details
Published in:Acta neuropathologica 1994-06, Vol.87 (6), p.568-571
Main Authors: FURUHATA, S, KAMEYA, T, TSURUTA, T, NARITAKA, H, TOYA, S
Format: Article
Language:English
Subjects:
Acromegaly - metabolism
Adenoma - metabolism
Adolescent
Adult
Aged
Biological and medical sciences
Child
Endocrinopathies
Female
Glycoprotein Hormones, alpha Subunit - metabolism
Growth Hormone - metabolism
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Immunohistochemistry - methods
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Neoplasms - metabolism
Staining and Labeling
Tissue Distribution
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Summary:Thirty-one consecutive cases of pituitary adenoma in acromegalic patients were studied by immunohistochemistry. All adenomas contained cells immunoreactive with the anti-alpha-subunit of gonadotropic hormones (alpha; 0.6-53% of tumor cells) as well as with anti-growth hormone (GH; 4-74% of tumor cells). In serial section study, most cells immunoreactive with anti-alpha were identical to cells immunoreactive with anti-GH. There was a positive correlation between the percentages of cells immunoreactive for alpha in GH cells [alpha (%)/GH(%)] and those for prolactin (PRL) in immunoreactive tumor cells (PRL(%)/[PRL(%) + GH(%)]) in mixed GH cell-PRL cell adenomas, suggesting that the alpha-subunit may play a role in emergence of PRL cells.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00293316