Non-uniform distribution of sister chromatid exchanges in human lymphocytes

To test whether sister chromatid exchange (SCE) scores on human chromosomes have a uniform distribution, simulated SCE scores were generated and compared with observed scores using log-linear models. The analysis was performed at the level of the chromosome groups. Using this method we first tested...

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Bibliographic Details
Published in:Chromosoma 1986, Vol.93 (3), p.197-202
Main Authors: VERCAUTEREN, P, MEULEPAS, E, VLIETINCK, R, CASSIMAN, J.-J, VAN DEN BERGHE, H
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cells, Cultured
Chromosome Banding
Cytogenetics
DNA - analysis
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Lymphocytes - cytology
Probability
Reference Values
Sister Chromatid Exchange
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Summary:To test whether sister chromatid exchange (SCE) scores on human chromosomes have a uniform distribution, simulated SCE scores were generated and compared with observed scores using log-linear models. The analysis was performed at the level of the chromosome groups. Using this method we first tested whether the number of SCEs was distributed uniformly, i.e. proportional to the relative length of the chromosomes. Refinements of this hypothesis were made by considering a variable region around a first SCE to be inert for other SCEs and by making the occurrence of an SCE on a chromosome dependent on the occurrence of another SCE on the same chromosome. In further analyses it was tested whether the number of SCEs was proportional to the number of G bands on a chromosome, or to the DNA content of the chromosomes. None of the tested hypotheses fitted the observed data, establishing the non-uniform distribution of these events.
ISSN:0009-5915
1432-0886
DOI:10.1007/BF00292738