Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells

Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without affecting...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-09, Vol.265 (5180), p.1869-1871
Main Authors: McMenamin, C, Pimm, C, McKersey, M, Holt, P G
Format: Article
Language:English
Subjects:
Animals
CD4 lymphocytes
CD4-Positive T-Lymphocytes - immunology
Dose-Response Relationship, Immunologic
Immune response
Immune Tolerance
Immunoglobulin E
Immunoglobulin E - biosynthesis
Immunoglobulin G - biosynthesis
Immunotherapy, Adoptive
Interferon-gamma - biosynthesis
Interleukin-2 - biosynthesis
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Ovalbumin - immunology
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocyte Subsets - immunology
Transforming Growth Factor beta - biosynthesis
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Summary:Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without affecting parallel IgG responses. Challenge of these gamma delta T cells in vitro with specific antigen resulted in production of high levels of interferon gamma. The effects of the gamma delta T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for specific CD4 TH2 cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7916481