d -Amphetamine Conditioned Place Preference in Developing Mice: Relations With Changes in Activity and Stereotypies

Conditioned place preference (CPP) with both visual and tactile cues, hyperactivity, and stereotypies produced by d -amphetamine (1-10 mg/kg ip, single dose) were studied in CD-1 mice at 2, 3, and 4 weeks from birth. CPP was shown from the youngest age onward in female mice and from 3 weeks in male...

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Bibliographic Details
Published in:Behavioral neuroscience 1994-06, Vol.108 (3), p.514-524
Main Authors: Laviola, Giovanni, Dell'Omo, Giacomo, Chiarotti, Flavia, Bignami, Giorgio
Format: Article
Language:English
Subjects:
Activity Level
Age Factors
Amphetamines
Animal
Animal behavior
Animal Development
Animals
Association Learning - drug effects
Biological and medical sciences
Choice Behavior - drug effects
Cocaine
Conditioning, Classical - drug effects
Cues
Dextroamphetamine
Dextroamphetamine - pharmacology
Dose-Response Relationship, Drug
Female
Infants (Animal)
Male
Medical sciences
Mice
Motor Activity - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Place Conditioning
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rodents
Social Environment
Stereotyped Behavior
Stereotyped Behavior - drug effects
Touch - drug effects
Visual Perception - drug effects
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Summary:Conditioned place preference (CPP) with both visual and tactile cues, hyperactivity, and stereotypies produced by d -amphetamine (1-10 mg/kg ip, single dose) were studied in CD-1 mice at 2, 3, and 4 weeks from birth. CPP was shown from the youngest age onward in female mice and from 3 weeks in male mice. Hyperactivity was much more pronounced in postweanlings (3 and 4 weeks) than in preweanlings. Stereotypies (at 3.3 and 10 mg/kg) occurred from the youngest age and tended to peak at 3 weeks. Stereotypies may indicate a sickness experience or "poor welfare" ( G. J. Mason, 1991 ; A. Wall, R. E. Hinson, E. Schmidt, C. Johnston, & A. Streather, 1990 ) due to an aversive component of amphetamine's action. Therefore, the delayed development of fully fledged amphetamine CPP, relative to cocaine CPP ( G. Laviola, G. Dell'Omo, E. Alleva, & G. Bignami, 1992 ), may be due to an age-dependent diminution of the positive hedonic value of the former drug by negative effects that are minimal or absent in the case of the latter drug.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.108.3.514