STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS: III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(AROMATIC HETEROCYCLIC SU BSTITUTED)AZETIDIN-2-ONES

The relationship between structure and antibacterial activity among monocyclic β-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(1), pp.76-89
Main Authors: YOSHIDA, CHOSAKU, TANAKA, KIYOSHI, NAKANO, JOJI, TODD, YOZO, YAMAFUJI, TETSUO, HATTORI, RIKIZO, FUKUOKA, YOSHIKAZU, SAIKAWA, ISAMU
Format: Article
Language:English
Subjects:
Acylation
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
beta-Lactams - chemical synthesis
beta-Lactams - pharmacology
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Organic chemistry
Preparations and properties
Structure-Activity Relationship
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The relationship between structure and antibacterial activity among monocyclic β-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.76