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STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS: III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(AROMATIC HETEROCYCLIC SU BSTITUTED)AZETIDIN-2-ONES

The relationship between structure and antibacterial activity among monocyclic β-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.

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Published in:	Journal of antibiotics 1986, Vol.39(1), pp.76-89
Main Authors:	YOSHIDA, CHOSAKU, TANAKA, KIYOSHI, NAKANO, JOJI, TODD, YOZO, YAMAFUJI, TETSUO, HATTORI, RIKIZO, FUKUOKA, YOSHIKAZU, SAIKAWA, ISAMU
Format:	Article
Language:	English
Subjects:	Acylation Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology beta-Lactams - chemical synthesis beta-Lactams - pharmacology Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Organic chemistry Preparations and properties Structure-Activity Relationship
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cited_by	cdi_FETCH-LOGICAL-c4166-2af186b073885a6d180f1bf0bfb2617ac2cae02ab70fc66ecebd6d1cc96534193
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container_end_page	89
container_issue	1
container_start_page	76
container_title	Journal of antibiotics
container_volume	39
creator	YOSHIDA, CHOSAKU TANAKA, KIYOSHI NAKANO, JOJI TODD, YOZO YAMAFUJI, TETSUO HATTORI, RIKIZO FUKUOKA, YOSHIKAZU SAIKAWA, ISAMU
description	The relationship between structure and antibacterial activity among monocyclic β-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.
doi_str_mv	10.7164/antibiotics.39.76
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subjects	Acylation Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology beta-Lactams - chemical synthesis beta-Lactams - pharmacology Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Organic chemistry Preparations and properties Structure-Activity Relationship
title	STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS: III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(AROMATIC HETEROCYCLIC SU BSTITUTED)AZETIDIN-2-ONES
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