THE SYNTHESIS AND BIOLOGICAL EVALUATION OF 7β-[2-(5-AMINO- [1, 2, 4]OXADIAZOL-3-YL)-2-Z-METHOXIMINOACETAMIDO]- CEPHALOSPORIN DERIVATIVES

A series of 7β-[2-(5-aminooxadiazol-3-yl)-2-Z-methoximinoacetamido]-3-cephem-4-carboxylic acids (7a-g) were synthesized and evaluated microbiologically. Although somewhat less active than cefotaxime 7a-g showed good antimicrobial activity against a wide variety of Gram-positive and Gram-negative bac...

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(1), pp.111-120
Main Authors: WHEELER, WILLIAM J., DEETER, JACK B., FINLEY, DON R., KINNICK, MICHAEL D., KOEHLER, RICHARD, OBSORNE, HAROLD E., OTT, JOHN T., SWARTZENDRUBER, JOHN K., WISHKA, DONN G.
Format: Article
Language:English
Subjects:
beta-Lactamases - metabolism
Cephalosporins - chemical synthesis
Cephalosporins - pharmacology
Chemistry
Exact sciences and technology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Microbial Sensitivity Tests
Models, Molecular
Organic chemistry
Preparations and properties
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Summary:A series of 7β-[2-(5-aminooxadiazol-3-yl)-2-Z-methoximinoacetamido]-3-cephem-4-carboxylic acids (7a-g) were synthesized and evaluated microbiologically. Although somewhat less active than cefotaxime 7a-g showed good antimicrobial activity against a wide variety of Gram-positive and Gram-negative bacteria. The β-lactamase stability of 7a and 7f was also discussed.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.111