Anti-Idiotypic Antibody Vaccine for Type B Viral Hepatitis in Chimpanzees

Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity a...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1986-04, Vol.232 (4747), p.220-223
Main Authors: Kennedy, Ronald C., Eichberg, Jorg W., Lanford, Robert E., Dreesman, Gordon R.
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Animals
Anti idiotypic antibodies
Anti-antibodies
Antibodies
Antibody Formation
Antigens
Biological and medical sciences
Chimpanzees
Diseases
Dosage
Dose-Response Relationship, Immunologic
Fundamental and applied biological sciences. Psychology
Hepatitis antigens
Hepatitis B
Hepatitis B - immunology
Hepatitis B - prevention & control
Hepatitis B Antibodies - immunology
Hepatitis B virus
Humans
Immunoglobulin Idiotypes - immunology
Immunoglobulins
Immunologic research
Immunological research
Immunotherapy
Infant, Newborn
Infections
Medical research
Mice
Microbiology
Pan troglodytes
Prevention
Rabbits - immunology
Rats
Schistosoma mansoni - immunology
Trypanosoma - immunology
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
Viruses
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Description
Summary:Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity appeared to be against the anti-Id, since the anti-Id immunogen was shown to bind the chimpanzee anti-HBs. Two chimpanzees immunized with the anti-Id, along with two control animals that were either untreated or received a nonimmune rabbit immunoglobulin G preparation, were challenged with infectious hepatitis B virus. Both control chimpanzees developed clinical and serological characteristics consistent with an active hepatitis B virus infection, whereas the two anti-Id treated chimpanzees were protected from infection. Since chimpanzees provide a relevant model of a human response to hepatitis B virus immunization and infection, these results indicate that anti-Id preparations such as that described here might be candidates for vaccines against human diseases.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3952505