Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind, placebo-controlled crossover study

Gastroesophageal reflux (GER) is common among patients with asthma, and it has been speculated that high GER may exacerbate asthma in some. This study was designed to determine if suppression of acid reflux in patients with asthma would improve pulmonary function. A double-blind, placebo-controlled...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1994-10, Vol.39 (10), p.2127-2133
Main Authors: Meier, J H, McNally, P R, Punja, M, Freeman, S R, Sudduth, R H, Stocker, N, Perry, M, Spaulding, H S
Format: Article
Language:English
Subjects:
Adult
Asthma - drug therapy
Asthma - epidemiology
Asthma - physiopathology
Cross-Over Studies
Double-Blind Method
Esophagus - drug effects
Esophagus - physiopathology
Female
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - epidemiology
Gastroesophageal Reflux - physiopathology
Humans
Hydrogen-Ion Concentration
Male
Manometry
Middle Aged
Omeprazole - pharmacology
Omeprazole - therapeutic use
Placebos
Respiration - drug effects
Statistics, Nonparametric
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastroesophageal reflux (GER) is common among patients with asthma, and it has been speculated that high GER may exacerbate asthma in some. This study was designed to determine if suppression of acid reflux in patients with asthma would improve pulmonary function. A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis. Four of 15 (27%) asthma patients with GER were shown to have a > or = 20% net improvement in pulmonary function (FEV1) after treatment for six weeks with omeprazole. These results indicate that some patients with asthma and GER will have improved pulmonary function when acid GER is treated with omeprazole.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF02090360