Thyrotropin Releasing Hormone Levels in Human Cerebrospinal Fluid in Various Neurologic Diseases

• Published in: The American journal of the medical sciences 1986-03, Vol.291 (3), p.164-167
• Main Authors: Mitsuma, Terunori, Nogimori, Tsuyoshi, Sahashi, Ko, Adachi, Koshin, Kihara, Mikihiro, Murakami, Ken, Nakao, Naoki, Gonda, Mieko, Fujii, Katsuro, Okabe, Yutaka, Takahashi, Akira
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Animals; Biological and medical sciences; Cerebrospinal Fluid; Cerebrospinal fluid (biochemistry, cytology, circulation, manometry). Intracranial pressure determination; Child; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Multiple Sclerosis - cerebrospinal fluid; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - physiopathology; Rabbits - immunology; Radioimmunoassay; Spinal Cord Neoplasms - cerebrospinal fluid; Thyrotropin Releasing Hormone; Thyrotropin-Releasing Hormone - cerebrospinal fluid
• ISSN: 0002-9629; 1538-2990
• DOI: 10.1097/00000441-198603000-00004

Thyrotropin releasing hormone (TRH) in the human cerebrospinal fluid (CSF) of 102 patients with non-neurologic and neurologic diseases was measured by a specific TRH radioimmunoassay. TRH levels in CSF were 17.6±3.4pg/ml (mean±SE) in non-neurologic diseases. TRH levels in CSF were significantly elevated in cases of spinal cord tumor and multiple sclerosis (acute phase). Elevated TRH levels in CSF were decreased in these diseases by operation or prednisolone treatment, respectively. From these data, it is suggested that TRH is present in the human CSF and that measurement of TRH levels in CSF may be a useful indicator of the activity of certain neurologic diseases.