19-Bromo-1-hydroxymethylbilane a novel inhibitor of Uro'gen III synthase

A novel hydroxymethylbilane analog, 19-Br-HMB ( 11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition. A novel hydroxymethylbilane analog, 19-Br-HMB ( 11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows comp...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 1994-04, Vol.2 (4), p.267-277
Main Authors: Pichon, Clotilde, Atshaves, Barbara P., Danso-Danquah, Richmond, Stolowich, Neal J., Scott, A.Ian
Format: Article
Language:English
Subjects:
Binding, Competitive
In Vitro Techniques
Magnetic Resonance Spectroscopy
Uroporphyrinogen III Synthetase - antagonists & inhibitors
Uroporphyrinogens - biosynthesis
Uroporphyrinogens - chemical synthesis
Uroporphyrinogens - chemistry
Uroporphyrinogens - pharmacology
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Summary:A novel hydroxymethylbilane analog, 19-Br-HMB ( 11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition. A novel hydroxymethylbilane analog, 19-Br-HMB ( 11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)82170-7