Correlational Imaging of Thalamocortical Coupling in the Primary Visual Pathway of the Human Brain

While the anatomy of the human brain is well defined, the functional connectivity of its structures is far less understood. Modern neuroimaging techniques offer the unique opportunity of visualizing physiologic activation in central nervous structures and of identifying the elements underlying distr...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1994-11, Vol.14 (6), p.952-957
Main Authors: Kleinschmidt, Andreas, Merboldt, Klaus-Dietmar, Hänicke, Wolfgang, Steinmetz, Helmuth, Frahm, Jens
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - physiology
Brain Mapping
Cerebral Cortex - physiology
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Geniculate Bodies - physiology
Humans
Magnetic Resonance Imaging
Photic Stimulation
Thalamus - physiology
Vertebrates: nervous system and sense organs
Visual Pathways - physiology
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Summary:While the anatomy of the human brain is well defined, the functional connectivity of its structures is far less understood. Modern neuroimaging techniques offer the unique opportunity of visualizing physiologic activation in central nervous structures and of identifying the elements underlying distributed networks for information processing. Following improved spatial resolution of deoxyhemoglobin-sensitive magnetic resonance imaging, we were able to detect simultaneous signal changes in the lateral geniculate nucleus and primary visual cortex during periodic photic stimulation. Visualization of coupled activation by cross-correlation analysis resulted in the first demonstration of thalamocortical interaction in the primary visual pathway of the intact human brain.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1994.127