No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family : evidence for genetic heterogeneity

Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individu...

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Bibliographic Details
Published in:Human genetics 1994-10, Vol.94 (4), p.364-366
Main Authors: YU-LIN KO, SHIH-ANN CHEN, TANG, T. K, JIUNN-LEE LIN, CHERN-EN CHIANG, JIN-JER CHEN, MING-SHENG TENG, MAU-SONG CHANG, WEN-PIN LIEN, CHENG-WEN WU
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Child
China
chromosome 11
Chromosomes, Human, Pair 11
DNA - analysis
Female
Genetic Heterogeneity
Genetic Linkage
Heart
Humans
linkage analysis
long QT syndrome
Long QT Syndrome - genetics
Male
man
Medical sciences
Middle Aged
Pedigree
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Summary:Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individuals were diagnosed to be affected, according to electrocardiographic criteria. Two genomic DNA probes (c-Ha-ras-3'-HVR and insulin-5'-HVR) and one tetranucleotide repeat polymorphism (THZ) derived from chromosome 11p15.5 loci and previously demonstrated to be closely linked to LQT were used as probes to analyze this family. A lod score of less than -2 was noted for all three polymorphisms. Our data show that there was no evidence of linkage between these three loci and the gene for LQT in this studied family. We believe that this result provides additional evidence for genetic heterogeneity of LQT.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00201594