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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

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Bibliographic Details
Published in:	Journal of medicinal chemistry 1994-09, Vol.37 (20), p.3200-3204
Main Authors:	Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P
Format:	Article
Language:	English
Subjects:	4-Hydroxycoumarins - chemistry 4-Hydroxycoumarins - metabolism 4-Hydroxycoumarins - pharmacology AIDS/HIV Amino Acid Sequence Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Binding Sites Binding, Competitive Biological and medical sciences Biological Availability Crystallization Dogs Drug Design HIV Protease - metabolism HIV Protease Inhibitors - chemistry HIV-1 - drug effects HIV-1 - enzymology human immunodeficiency virus Hydrogen Bonding Medical sciences Models, Molecular Molecular Sequence Data Pharmacology. Drug treatments Pyrones - chemical synthesis Pyrones - chemistry Pyrones - metabolism Pyrones - pharmacokinetics Pyrones - pharmacology Rats
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