Immunoregulatory And Proinflammatory Cytokine Production In Visceral And Cutaneous Leishmaniasis

Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are the major parasitic diseases in which the immune system is implicated in pathogenesis. The in vitro production of interleukin (IL)-2, IL-4, IL-6, IL-8, tumor necrosis factor-a (TNFa), and granulocyte-macrophage colonystimulating factor...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-10, Vol.170 (4), p.1037-1040
Main Authors: Raziuddin, Syed, Abdalla, Rashid E., EI-Awad, EI-Hag, AI-Janadi, Mansour
Format: Article
Language:English
Subjects:
Blood
Cells, Cultured
Child
Child, Preschool
Concise Communication
Cutaneous leishmaniasis
Cytokines
Cytokines - biosynthesis
Female
Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis
Humans
Interleukins - biosynthesis
Leishmaniasis
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Visceral - immunology
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Lymphocyte Activation
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Neutrophils
Parasitic diseases
Pathogenesis
Reference Values
T lymphocytes
Tumor Necrosis Factor-alpha - biosynthesis
Visceral leishmaniasis
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Summary:Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are the major parasitic diseases in which the immune system is implicated in pathogenesis. The in vitro production of interleukin (IL)-2, IL-4, IL-6, IL-8, tumor necrosis factor-a (TNFa), and granulocyte-macrophage colonystimulating factor (GM-CSF), spontaneously and in response to stimulation of peripheral blood mononuclear cells with anti-CD3, phytohemagglutinin, and lipopolysaccharide, was investigated to determine their importance in VL and CL. Highly enhanced production of IL-4, IL-6, IL-8, and TNFa was seen in VL. However, enhanced production ofIL-4 and TNFa but almost normal production of IL-6 and IL-8 was seen in CL. The highly increased IL-4 production was the most characteristic and common feature of both VL and CL. Of interest, highly deficient GM-CSF production may be implicated in abnormalities in synthesis of hematopoietic lineage of cells in these diseases.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.4.1037