The Role Of Phagocytic Cells In Resistance To Disseminated Candidiasis In Granulocytopenic Mice

This study assessed the involvement of phagocytic cells in murine resistance to disseminated candidiasis of endogenous origin. SCID mice and their immunocompetent CB.17 (BALBjc) counterparts were colonized with a pure culture of Candida albicans and treated with an antigranulocyte monoclonal antibod...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-10, Vol.170 (4), p.900-905
Main Authors: Jensen, Jean, Warner, Thomas, Balish, Edward
Format: Article
Language:English
Subjects:
Abscess - microbiology
Abscess - pathology
Agranulocytosis - immunology
Agranulocytosis - microbiology
Animals
Antibodies, Monoclonal - pharmacology
Candida albicans
Candida albicans - isolation & purification
Candidiasis
Candidiasis - immunology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Granulocytes - drug effects
Immunity, Innate
Infections
Kidneys
Liver
Macrophages
Major Article
Mice
Mice, Inbred BALB C
Mice, SCID
Monoclonal antibodies
Pancreatic Diseases - microbiology
Pancreatic Diseases - pathology
Phagocytes - drug effects
Phagocytes - physiology
Poly I-C - pharmacology
Spleen
Stomach
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Summary:This study assessed the involvement of phagocytic cells in murine resistance to disseminated candidiasis of endogenous origin. SCID mice and their immunocompetent CB.17 (BALBjc) counterparts were colonized with a pure culture of Candida albicans and treated with an antigranulocyte monoclonal antibody (anti-Gr-l), polyinosinic:polycytidylic acid (poly[I‘b7 CD, or both to impair macrophage function in vivo. Candida-colonized SCID mice were more susceptible to disseminated candidiasis after treatment with anti-Gr-l or poly(l’b7 C) than were CB.17 mice. Histopathology of orogastric tissues demonstrated that combined treatments with antiGr-l and poly(I'b7 C) also enhanced the susceptibility of SCID and CB.17 mice to orogastric candidiasis. These data indicate that macrophages as well as granulocytes play an important role in host resistance to mucosal and disseminated candidiasis of endogenous origin.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.4.900