Production and secretion of immunoreactive growth hormone‐releasing factor by pheochromocytomas

The production and secretion of immunoreactive growth hormone‐releasing factor (IR‐GRF) by pheochromocytomas were examined immunohistochemically and immunochemically. GRF‐immunoreactive (GRF‐IR) cells were found, although sparsely, in 2 of 13 tumors (Cases 1 and 2), while somatostatin (SRIF)‐IR cell...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1986-05, Vol.57 (9), p.1788-1793
Main Authors: Sano, Toshiaki, Saito, Haruhiko, Yamasaki, Ryuichi, Hosoi, Eiji, Kameyama, Kazuhito, Saito, Shiro, Hirose, Takanori, Hizawa, Kazuo
Format: Article
Language:English
Subjects:
Adolescent
Adrenal Gland Neoplasms - metabolism
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adult
Aged
Applied sciences
Biological and medical sciences
Catecholamines - blood
Chromatography, Gel
Endocrinopathies
Exact sciences and technology
Female
Growth Hormone-Releasing Hormone - metabolism
Histocytochemistry
Humans
Immunoenzyme Techniques
Male
Malignant tumors
Medical sciences
Middle Aged
Other techniques and industries
Paraneoplastic Endocrine Syndromes - metabolism
Pheochromocytoma - metabolism
Radioimmunoassay
Somatostatin - analysis
Vasoactive Intestinal Peptide - analysis
Venae Cavae
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The production and secretion of immunoreactive growth hormone‐releasing factor (IR‐GRF) by pheochromocytomas were examined immunohistochemically and immunochemically. GRF‐immunoreactive (GRF‐IR) cells were found, although sparsely, in 2 of 13 tumors (Cases 1 and 2), while somatostatin (SRIF)‐IR cells and vasoactive intestinal peptide (VIP)‐IR cells were found in nine and five tumors, respectively. Concentrations of tissue IR‐GRF of 29.8 and 17.2 ng/g wet weight tissue, respectively, were found in two (Cases 1 and 2) of three tumors examined. These three tumors also contained IR‐SRIF at 19.5–105.5 ng/g wet weight tissue and IR‐VIP at 13.6–24.8 ng/g wet weight tissue. An increased plasma IR‐GRF concentration (30.0 pg/ml) was found in a blood sample taken from the inferior vena cava near the adrenal tumor in Case 1. This is the first report that some pheochromocytomas produce GRF and secrete it into the blood circulation.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19860501)57:9<1788::AID-CNCR2820570913>3.0.CO;2-3