Malignant fibrous histiocytoma complicating mitral valve replacement

A 67 year old woman developed a fatal febrile illness 8 years after mitral valve replacement for rheumatic valvular heart disease. The final disease persisted for 1 year and was characterized clinically by weakness, weight loss, congestive heart failure and multiple embolic events to the central ner...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 1986-04, Vol.7 (4), p.956-960
Main Authors: Holtzman, Eliezer, Schiby, Ginette, Segal, Pesach, Priel, Israel
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology. Vascular system
Endocardial and cardiac valvular diseases
Female
Heart
Heart Atria
Heart Failure - etiology
Heart Neoplasms - etiology
Heart Neoplasms - pathology
Heart Valve Prosthesis - adverse effects
Histiocytoma, Benign Fibrous - etiology
Histiocytoma, Benign Fibrous - pathology
Humans
Medical sciences
Mitral Valve - pathology
Mitral Valve - surgery
Necrosis
Neoplastic Cells, Circulating
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Summary:A 67 year old woman developed a fatal febrile illness 8 years after mitral valve replacement for rheumatic valvular heart disease. The final disease persisted for 1 year and was characterized clinically by weakness, weight loss, congestive heart failure and multiple embolic events to the central nervous system and abdominal organs. The source of the emboli was a tumor, malignant fibrous histiocytoma of the left atrium, originating from the anulus fibrosus around the covered base of the prosthetic valve. This unique case suggests the possibility that chronic exposure to materials, such as Dacron, covering prosthetic valves may induce local malignant tumors.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(86)80365-5