trithorax-like gene encodes the Drosophila GAGA factor

Little is known about the way higher-order chromatin structure influences gene expression and chromosome topology in general. Genetic analysis in Drosophila has led to the discovery of two classes of genes, the regulators of homeotic genes and the modifiers of position-effect variegation, which seem...

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Bibliographic Details
Published in:Nature (London) 1994-10, Vol.371 (6500), p.806-808
Main Authors: Farkas, G, Gausz, J, Galloni, M, Reuter, G, Gyurkovics, H, Karch, F
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
chromatin
Chromatin - genetics
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
DNA conformation
DNA Transposable Elements
DNA-binding proteins
DNA-Binding Proteins - genetics
Drosophila
Drosophila - genetics
Drosophila melanogaster
Drosophila Proteins
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Genes, Insect
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Homeodomain Proteins
Humanities and Social Sciences
Insects
Invertebrata
letter
Male
multidisciplinary
Mutation
Promoter Regions, Genetic
Science
Science (multidisciplinary)
structural genes
transcription factors
Transcription Factors - genetics
Zinc Fingers - genetics
Zoology
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Summary:Little is known about the way higher-order chromatin structure influences gene expression and chromosome topology in general. Genetic analysis in Drosophila has led to the discovery of two classes of genes, the regulators of homeotic genes and the modifiers of position-effect variegation, which seem to be good candidates for encoding some of the factors regulating chromatin functions. The Trithorax-like gene we describe here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation. We found that Trithorax-like encodes the GAGA factor which is involved in the formation of an accessible chromatin structure at promoter sequences . Our genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions.
ISSN:0028-0836
1476-4687
DOI:10.1038/371806a0