Hypersplenism-effect on haemostasis: an experimental study in the rat

Hypersplenism induced by methylcellulose given to rats i.p. was characterized by splenomegaly, anaemia, leucocytopenia and thrombocytopenia. Hb, Hct and WBC count were normalized, and platelet count rose to supernormal values by splenectomy. At a standardized liver resection, the hypersplenic rats h...

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Bibliographic Details
Published in:Research in experimental medicine 1986, Vol.186 (1), p.21-27
Main Authors: ALWMARK, A, BENGMARK, S, GULLSTRAND, P, ZOUCAS, E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bleeding Time
Hematologic and hematopoietic diseases
Hemorrhage - etiology
Hemostasis
Hypersplenism - blood
Hypersplenism - physiopathology
Hypersplenism - surgery
Male
Medical sciences
Methylcellulose
Partial Thromboplastin Time
Platelet Aggregation
Platelet Count
Platelet diseases and coagulopathies
Rats
Rats, Inbred Strains
Splenectomy
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Summary:Hypersplenism induced by methylcellulose given to rats i.p. was characterized by splenomegaly, anaemia, leucocytopenia and thrombocytopenia. Hb, Hct and WBC count were normalized, and platelet count rose to supernormal values by splenectomy. At a standardized liver resection, the hypersplenic rats had an increased blood loss and prolonged bleeding time in comparison with control rats. Removal of the large spleen normalized these abnormalities. Hypersplenism also shortened APT time and impaired ADP and collagen-induced platelet aggregation, findings not normalized by splenectomy.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF01851830