Platelet MAO concentration and molecular activity: II. Comparison of normal and schizophrenic populations

Platelet monoamine oxidase (MAO B) in 59 normal and 57 RDC- diagnosed medicated and unmedicated schizophrenic subjects was analyzed for whole platelet and extracted activities, specific concentration, and molecular activity. A novel radioimmunoassay using a monoclonal antibody elicited to human plat...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 1986-02, Vol.17 (2), p.141-151
Main Authors: Rose, Robert M., Castellani, Sam, Boeringa, J.Alexander, Malek-Ahmadi, Parvis, Lankford, D.Alan, Bessman, J.David, Fritz, Richard R., Denney, Constance B., Denney, Richard M., Abell, Creed W.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal
Antibody Specificity
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Blood Platelets - enzymology
enzyme concentration
Female
Humans
Isoenzymes - blood
Kinetics
Male
Medical sciences
Miscellaneous
molecular enzyme activity
Monoamine Oxidase - blood
Monoamine oxidase B
monoclonal antibodies
neuroleptics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radioimmunoassay - methods
schizophrenia
Schizophrenia - drug therapy
Schizophrenia - enzymology
Sex Factors
Techniques and methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Platelet monoamine oxidase (MAO B) in 59 normal and 57 RDC- diagnosed medicated and unmedicated schizophrenic subjects was analyzed for whole platelet and extracted activities, specific concentration, and molecular activity. A novel radioimmunoassay using a monoclonal antibody elicited to human platelet MAO was used. Female schizophrenics showed no differences from female normals in MAO measures; however, these data could not be clearly evaluated because of confounding effects of age and drugs. Male schizophrenics treated with neuroleptics expressed significantly reduced whole platelet MAO activity, compared to untreated male patients. Compared with normal males, male schizophrenics showed significantly lowered molecular activities, along with elevated specific concentrations, which did not appear to be explained solely by drug usage. Additional mechanisms explaining the diminished molecular activity in male schizophrenics may be the presence of an endogenous irreversible inhibitor or a genetically determined, possibly structural, variant of MAO B.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(86)90069-7