Effect of intracerebroventricular injection of prostaglandin E2 on anterior pituitary cell proliferation

The influence of an intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2) on the mitotic activity of the rat anterior pituitary was investigated. It was found that i.c.v. PGE2 (3 micrograms/20 microliters) resulted in a significant decrease of the mitotic activity in the anterior pit...

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Bibliographic Details
Published in:Research in experimental medicine 1986, Vol.186 (1), p.1-4
Main Authors: SEWERYNEK, E, LEWINSKI, A, KONOPACKI, J, PAWLIKOWSKI, M, LEWINSKA, M. K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Dinoprostone
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Injections, Intraventricular
Male
Mitosis - drug effects
Pituitary Gland, Anterior - cytology
Pituitary Gland, Anterior - drug effects
Prostaglandins E - administration & dosage
Prostaglandins E - pharmacology
Rats
Rats, Inbred Strains
Vertebrates: endocrinology
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Summary:The influence of an intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2) on the mitotic activity of the rat anterior pituitary was investigated. It was found that i.c.v. PGE2 (3 micrograms/20 microliters) resulted in a significant decrease of the mitotic activity in the anterior pituitary. This drop involved mainly chromophobic cells. No mitoses were found in acidophilic cells either in controls or in PGE2-treated rats. It is suggested that PGE2 may release an unidentified hypothalamic factor which inhibits the cell proliferation of the anterior pituitary.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF01851827