Anatomical Evidence for Cerebellar and Basal Ganglia Involvement in Higher Cognitive Function

The possibility that neurons in the basal ganglia and cerebellum innervate areas of the cerebral cortex that are involved in cognitive function has been a controversial subject. Here, retrograde transneuronal transport of herpes simplex virus type 1 (HSV1) was used to identify subcortical neurons th...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-10, Vol.266 (5184), p.458-461
Main Authors: Middleton, Frank A., Strick, Peter L.
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
Basal ganglia
Basal Ganglia - anatomy & histology
Basal Ganglia - physiology
Behavioral neuroscience
Behavioral psychophysiology
Biological and medical sciences
Brain
Brain Mapping
Cebus
Cerebellar Nuclei - anatomy & histology
Cerebellar Nuclei - physiology
Cerebellum
Cerebellum - anatomy & histology
Cerebellum - physiology
Cerebral cortex
Cognition
Fundamental and applied biological sciences. Psychology
Globus Pallidus - anatomy & histology
Globus Pallidus - physiology
Herpesvirus 1, Human - physiology
Injection sites
Innervation
Localization (Brain function)
Localization of functions
Memory
Neural Pathways
Neurons
Neurons - cytology
Physiological aspects
Prefrontal cortex
Prefrontal Cortex - anatomy & histology
Prefrontal Cortex - physiology
Primates
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Thalamic Nuclei - anatomy & histology
Thalamic Nuclei - physiology
Thalamus
Viruses
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Description
Summary:The possibility that neurons in the basal ganglia and cerebellum innervate areas of the cerebral cortex that are involved in cognitive function has been a controversial subject. Here, retrograde transneuronal transport of herpes simplex virus type 1 (HSV1) was used to identify subcortical neurons that project via the thalamus to area 46 of the primate prefrontal cortex. This cortical area is known to be involved in spatial working memory. Many neurons in restricted regions of the dentate nucleus of the cerebellum and in the internal segment of the globus pallidus were labeled by transneuronal transport of virus from area 46. The location of these neurons was different from those labeled after HSV1 transport from motor areas of the cerebral cortex. These observations define an anatomical substrate for the involvement of basal ganglia and cerebellar output in higher cognitive function.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7939688