Epstein-Barr virus infection in sinonasal non-Hodgkin's lymphomas

• Published in: Virchows Archiv : an international journal of pathology 1994-09, Vol.425 (2), p.121-125
• Main Authors: LUZI, P, LEONCINI, L, FUNTO, I, BRUNI, A, LAZZI, S, PACENTI, L, TOSI, P
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Base Sequence; Biological and medical sciences; Female; Gene Rearrangement, B-Lymphocyte - genetics; Gene Rearrangement, T-Lymphocyte - genetics; Hematologic and hematopoietic diseases; Herpesviridae Infections - diagnosis; Herpesvirus 4, Human - isolation & purification; Humans; Immunoenzyme Techniques; In Situ Hybridization; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Non-Hodgkin - virology; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Nose Neoplasms - virology; Paranasal Sinus Neoplasms - virology; Polymerase Chain Reaction; RNA, Viral - analysis; Tumor Virus Infections - diagnosis
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/BF00230347

Sinonasal non-Hodgkin's lymphomas (SNHLs) of B- or T-cell immunophenotype have been associated with Epstein-Barr virus (EBV) infection of neoplastic lymphoid tissue. Nine SNHLs were investigated using immunohistochemistry, the polymerase chain reaction (PCR) for EBV genome and in situ hybridization (ISH) for EBV encoded RNAs (EBER), immunoglobulin (CI-gHR) and clonal T-cell receptor (CTC beta R) gene rearrangements. Eight cases were diagnosed as peripheral pleomorphic T-cell lymphomas (pPTCL). PCR showed the presence of EBV genome in eight cases; ISH for EBER led to the detection of positive cells in five cases. Late membrane protein (LMP) immunostaining was observed in three cases. No EBV positivity has been detected in control cases. The frequent association with EBV infection in the cases illustrated confirms the previous suggestions that EBV may have a role in the genesis of lymphomas of the sinonasal region.