Yohimbine premedication and 35% CO2 vulnerability in healthy volunteers

A group of 20 healthy volunteers underwent a 35% carbon dioxide/65% oxygen air-placebo controlled challenge test twice, premedicated 1 h before with either 20 mg yohimbine or placebo, following a double-blind randomized crossover design. Contrary to expectation the anxiety response to carbon dioxide...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 1994-08, Vol.244 (2), p.81-85
Main Authors: POLS, H, GRIEZ, E, VERBURG, K, VAN DER WERF, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Anxiety - chemically induced
Anxiety - physiopathology
Anxiety disorders. Neuroses
Biological and medical sciences
Carbon Dioxide
Female
Humans
Locus Coeruleus - drug effects
Locus Coeruleus - physiopathology
Male
Medical sciences
Norepinephrine - physiology
Panic - drug effects
Panic - physiology
Panic disorder
Premedication
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Yohimbine - pharmacology
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Summary:A group of 20 healthy volunteers underwent a 35% carbon dioxide/65% oxygen air-placebo controlled challenge test twice, premedicated 1 h before with either 20 mg yohimbine or placebo, following a double-blind randomized crossover design. Contrary to expectation the anxiety response to carbon dioxide was not higher when premedicated with yohimbine compared to premedication with placebo. Possible implications of this finding are discussed, with reference to general chemical models of panic.
ISSN:0940-1334
1433-8491
DOI:10.1007/BF02193523