Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells

FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morph...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1994-09, Vol.58 (9), p.1579-1583
Main Authors: Ueda, H, Nakajima, H, Hori, Y, Goto, T, Okuhara, M
Format: Article
Language:English
Subjects:
3T3 Cells - drug effects
3T3 Cells - physiology
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics, Antineoplastic - pharmacology
Biotechnology
Blotting, Northern
Cell Cycle - drug effects
Cell Division - drug effects
Cell Line, Transformed
Cell Nucleus - drug effects
Cell Nucleus - metabolism
Chromobacterium - metabolism
Depsipeptides
DNA, Neoplasm - biosynthesis
Flow Cytometry
Gene Expression - drug effects
Genes, myc - drug effects
Genes, ras - drug effects
Kinetics
Macromolecular Substances
Mice
Peptides, Cyclic
Signal Transduction - drug effects
Transfection
Transformation, Genetic - drug effects
Urinary Bladder Neoplasms - genetics
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Summary:FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morphological reversion of the transformed cells to normal were correlated with growth inhibition (G0/G1 arrest in cell cycle).
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.58.1579