Soluble intercellular adhesion molecule-1 in serum in chronic hepatitis B and C

Intercellular adhesion molecule-1 (ICAM-1) is expressed on the hepatocyte membrane in patients with chronic hepatitis B and C. We assayed levels of the soluble form of this molecule (sICAM-1) in serum by an enzyme-linked immunosorbent assay method; we then analyzed the results in relation to hepatit...

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Bibliographic Details
Published in:Journal of gastroenterology 1994-08, Vol.29 (4), p.455-459
Main Authors: Horiike, N, Onji, M, Kumamoto, I, Masumoto, T
Format: Article
Language:English
Subjects:
Adult
Aged
Alanine Transaminase - blood
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis B - enzymology
Hepatitis B - immunology
Hepatitis C - enzymology
Hepatitis C - immunology
Humans
Immunohistochemistry
Intercellular Adhesion Molecule-1 - blood
Liver - immunology
Male
Middle Aged
Predictive Value of Tests
Solubility
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Summary:Intercellular adhesion molecule-1 (ICAM-1) is expressed on the hepatocyte membrane in patients with chronic hepatitis B and C. We assayed levels of the soluble form of this molecule (sICAM-1) in serum by an enzyme-linked immunosorbent assay method; we then analyzed the results in relation to hepatitis activity. Fifty-one patients with chronic hepatitis (22 with type B and 29 with type C) and 10 normal controls were examined. The serum levels of sICAM-1 in hepatitis B and C were significantly higher (P < 0.01) than in normal controls. The serum level of sICAM-1 was correlated with serum glutamic-pyruvic transaminase level (P < 0.01), and the level of sICAM-1 in patients in whom exacerbation was seen was significantly higher (P < 0.05) than that in patients in a remission. There was no relationship between the serum level of sICAM-1 and the degree of ICAM-1 expression on the hepatocyte membrane. These results suggest that the serum level of sICAM-1 reflects the degree of activity of chronic hepatitis B and C.
ISSN:0944-1174
1435-5922
DOI:10.1007/BF02361243