Interrelationships of the "Ly-6 complex" antigens

Competitive binding studies and immunoprecipitation experiments define at least five distinct epitopes encoded by Ly-6-linked genes--Ly-6A.2, Ly-6B.2, Ly-6C.2, Ly-6D.2, and ThB. Ly-6A.2, a 33 kd protein, and Ly-6D.2 are closely overlapping epitopes that can be distinguished by their unique thymus re...

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Bibliographic Details
Published in:Immunogenetics (New York) 1986-01, Vol.23 (4), p.226-232
Main Authors: Houlden, B A, Hogarth, P M, McKenzie, I F
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Antibody Specificity
Antigens, Ly - classification
Antigens, Ly - immunology
Antigens, Surface - classification
Antigens, Surface - immunology
Bone Marrow - immunology
Cell Membrane - immunology
Cell Membrane - ultrastructure
Epitopes
Mice
Spleen - immunology
Tissue Distribution
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Summary:Competitive binding studies and immunoprecipitation experiments define at least five distinct epitopes encoded by Ly-6-linked genes--Ly-6A.2, Ly-6B.2, Ly-6C.2, Ly-6D.2, and ThB. Ly-6A.2, a 33 kd protein, and Ly-6D.2 are closely overlapping epitopes that can be distinguished by their unique thymus reactions of 10-20% or greater than 90%, respectively. Similarly, the Ly-6C.2 antigen present on a 14 kd moiety loosely overlaps the Ly-6B.2 antigen. Ly-6C.2 and Ly-6B.2 antigens are distinct from Ly-6A.2 and Ly-6D.2, however. ThB is a 16-18 kd antigen which is not associated on the cell surface with any other "Ly-6" antigens. In addition, independently derived antibodies made to the Ly-6C.2 antigen detect an identical epitope, as do antibodies to Ly-6A.2 and Ly-6B.2. These results imply the existence of a single antigenic site on each of these molecules.
ISSN:0093-7711
1432-1211
DOI:10.1007/BF00373017