Liposteroid against refractory pulmonary haemorrhage in idiopathic pulmonary haemosiderosis

We describe two Japanese children with idiopathic pulmonary haemosiderosis (IPH), whose refractory haemorrhages were treated with an intravenous lipid emulsion containing dexamethasone (liposteroid). A 22-month-old boy and a 14-month-old girl have been observed with similar symptoms; periodic bouts...

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Bibliographic Details
Published in:European journal of pediatrics 1994-09, Vol.153 (9), p.687-690
Main Authors: SHOUICHI OHGA, NOMURA, A, SUGA, N, HIKINO, S, KIRA, R, MATSUZAKI, A, MASUDA, K, UEDA, K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dexamethasone - therapeutic use
Female
Hemorrhage - complications
Hemorrhage - drug therapy
Hemosiderosis - complications
Hemosiderosis - diagnosis
Hemosiderosis - drug therapy
Humans
Infant
Lung Diseases - complications
Lung Diseases - drug therapy
Male
Medical sciences
Methylprednisolone - therapeutic use
Pneumology
Recurrence
Respiratory system : syndromes and miscellaneous diseases
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Summary:We describe two Japanese children with idiopathic pulmonary haemosiderosis (IPH), whose refractory haemorrhages were treated with an intravenous lipid emulsion containing dexamethasone (liposteroid). A 22-month-old boy and a 14-month-old girl have been observed with similar symptoms; periodic bouts of anaemia, reticulocytosis, diffuse infiltrates on chest X-ray and the finding of siderophages in sputum or gastric lavage fluid. The MRI of the lung was useful for the diagnosis. Methylprednisolone pulse therapy was successful in treating acute massive bleeding. Subsequent oral prednisolone could not prevent chronic recurrent haemorrhages. However, the intermittent administration of liposteroid (0.05 mg/kg/dose IV) led to a cessation of bleeding; the haemoglobin concentration rose to normal levels. This observation emphasizes the usefulness of liposteroid in the management of refractory IPH.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF02190693