Pharmacokinetics of ganciclovir in a patient undergoing chronic haemodialysis

The pharmacokinetics of ganciclovir was evaluated in a 73-year old anuric, haemodialyzed patient given 1.25 mg.kg-1 at the end of each haemodialysis session, three times per week. A biexponential decrease in plasma ganciclovir was observed, with a peak concentration of 3.7 mg.l-1 followed by a stead...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1994, Vol.46 (4), p.379-381
Main Authors: COMBARNOUS, F, FOUQUE, D, BERNARD, N, BOULIEU, R, CHOSSEGROS, P, LAVILLE, M, ZECH, P
Format: Article
Language:English
Subjects:
Aged
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Anuria - metabolism
Biological and medical sciences
Ganciclovir - administration & dosage
Ganciclovir - blood
Ganciclovir - pharmacokinetics
Humans
Infusions, Intravenous
Male
Medical sciences
Metabolic Clearance Rate
Pharmacology. Drug treatments
Renal Dialysis
Time Factors
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Summary:The pharmacokinetics of ganciclovir was evaluated in a 73-year old anuric, haemodialyzed patient given 1.25 mg.kg-1 at the end of each haemodialysis session, three times per week. A biexponential decrease in plasma ganciclovir was observed, with a peak concentration of 3.7 mg.l-1 followed by a steady state value of 2.6 mg.l-1 for almost 40 h. The total plasma clearance was 0.05 ml.min-1.kg-1, the volume of distribution at steady state was 0.6 l.kg-1, the elimination half life was 132 h, the area under curve was 372 micrograms.h.ml-1, the mean residence time was 190 h, and the percentage of ganciclovir cleared from plasma after a 5 h haemodialysis session was 52.1%. The simulated pharmacokinetics over one month, following the same scheme of administration, did not suggest marked accumulation of ganciclovir. These results were obtained after a reduction of 58% in the recommended dose in patients with impaired renal function.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00194410