Autocrine tumor growth regulation and tumor-associated hypoglycemia in murine melanoma B16 in vivo

A substance immunochemically cross-reactive with insulin (SICRI) appears in melanoma B16 growing in diabetic and nondiabetic C57BL/6 mice. Progression of tumor size is paralleled by the increase of SICRI levels in the serum of both diabetic and nondiabetic animals; this increase correlates with a de...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1986-05, Vol.46 (5), p.2208-2213
Main Authors: VUK-PAVLOVIC, S, OPARA, E. C, LEVANAT, S, VRBANEC, D, PAVELIC, K
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Diabetes Mellitus, Experimental - complications
Epidermal Growth Factor - pharmacology
Experimental skin tumors
Fibroblast Growth Factors - pharmacology
Growth Hormone - pharmacology
Homeostasis
Hypoglycemia - etiology
Insulin - blood
Medical sciences
Melanoma - complications
Melanoma - pathology
Melanoma - physiopathology
Mice
Platelet-Derived Growth Factor - pharmacology
Somatomedins - pharmacology
Tumors
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Summary:A substance immunochemically cross-reactive with insulin (SICRI) appears in melanoma B16 growing in diabetic and nondiabetic C57BL/6 mice. Progression of tumor size is paralleled by the increase of SICRI levels in the serum of both diabetic and nondiabetic animals; this increase correlates with a decreased concentration of circulating glucose and an elevated concentration of growth hormone in blood. Melanoma B16 grown under serum-free culture conditions secretes SICRI into the medium. Affinity-purified SICRI stimulates glucose uptake by rat epididymal adipocytes and competes with radiolabeled insulin for binding to these cells. Low concentrations of SICRI enhance growth of cultured melanoma B16 cells, whereas high concentrations of this substance have inhibitory growth effects on these cells. Porcine insulin, human insulin-like growth factors I and II, human growth hormone, platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor have negligible influence on growth of melanoma B16.
ISSN:0008-5472
1538-7445