Treatment of symptomatic hepatic cysts by percutaneous instillation of minocycline hydrochloride

Nine patients with 16 symptomatic nonneoplastic congenital hepatic cysts were treated prospectively by ultrasonically guided percutaneous minocycline hydrochloride injection, and the usefulness of this treatment was evaluated. Seven of the patients had multiple hepatic cysts, and two solitary cysts....

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Bibliographic Details
Published in:Digestive diseases and sciences 1994-11, Vol.39 (11), p.2503-2509
Main Authors: YAMADA, N, SHINZAWA, H, UKAI, K, MAKINO, N, MATSUHASHI, T, WAKABAYASHI, H, TOGASHI, H, TAKAHASHI, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cysts - congenital
Cysts - diagnostic imaging
Cysts - drug therapy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Injections
Liver Diseases - congenital
Liver Diseases - diagnostic imaging
Liver Diseases - drug therapy
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Minocycline - administration & dosage
Minocycline - therapeutic use
Prospective Studies
Punctures
Tumors
Ultrasonography, Interventional
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Summary:Nine patients with 16 symptomatic nonneoplastic congenital hepatic cysts were treated prospectively by ultrasonically guided percutaneous minocycline hydrochloride injection, and the usefulness of this treatment was evaluated. Seven of the patients had multiple hepatic cysts, and two solitary cysts. All the patients were women, ranging in age from 36 to 81 years. After cystic fluid had been aspirated with a 21-gauge PTC needle, minocycline hydrochloride was injected into all the cysts. The minocycline hydrochloride was dissolved in saline at a concentration of 200 mg in 9 ml, and mixed with 1 ml of 2% mepivacaine hydrochloride. The total quantity of minocycline hydrochloride injected varied from 100 mg to 1200 mg per hepatic cyst, depending on its size. Total or subtotal regression of the cysts was observed in all patients during follow-up periods ranging from 15 to 35 months. Seven patients became symptom-free, one showed symptom reduction, and one showed no change in symptoms. Minor side effects, eg, transient abdominal pain, slight right shoulder pain, and temperature elevation, were noted in three patients respectively. On the basis of these results, we conclude that ultrasonically guided percutaneous minocycline hydrochloride injection is useful for the treatment of symptomatic hepatic cysts.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf02087673