Kidney and liver contributions of salicylate metabolism in rats

The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1994-01, Vol.19 (1), p.21-26
Main Authors: LAZNICEK, M, LAZNICKOVA, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotransformation
Bones, joints and connective tissue. Antiinflammatory agents
Gluconates - metabolism
Gluconates - urine
Glycine - metabolism
Glycine - urine
Half-Life
In Vitro Techniques
Kidney - metabolism
Liver - metabolism
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Salicylates - pharmacokinetics
Salicylates - urine
Salicylic Acid
Technetium Tc 99m Pentetate
Tissue Distribution
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Summary:The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03188818