Two novel HMW MAP2 variants with four microtubule-binding repeats and different projection domains

The brain microtubule-associated protein MAP2 is composed of two high molecular (MAP2a and b) and one low molecular (MAP2c) weight isoforms. All these forms were thought to contain three repeated microtubule-binding domains in their C-terminal region but a MAP2c variant containing four repeats has r...

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Bibliographic Details
Published in:FEBS letters 1994-11, Vol.354 (3), p.259-262
Main Authors: Langkopf, Anja, Guilleminot, Jocelyne, Nunez, Jacques
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Cell Differentiation
Cell Fusion
Cytoskeleton
Genetic Variation
MAP2a/b
Microtubule
Microtubule-Associated Proteins - chemistry
Microtubule-Associated Proteins - genetics
Microtubules - metabolism
Molecular Sequence Data
Molecular Weight
Neuroblastoma
Neuron
Neurons - chemistry
Polymerase Chain Reaction
Rats
Repetitive Sequences, Nucleic Acid
Tumor Cells, Cultured
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Summary:The brain microtubule-associated protein MAP2 is composed of two high molecular (MAP2a and b) and one low molecular (MAP2c) weight isoforms. All these forms were thought to contain three repeated microtubule-binding domains in their C-terminal region but a MAP2c variant containing four repeats has recently been identified. We report here the existence of two high molecular weight MAP2 isoforms with four microtubule-binding domains in the sensory neuronal cell line ND 7/23. A stretch of 135 bp is missing in one of these forms suggesting that several HMW MAP2 variants can be produced by alternative splicing.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)01128-1