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Two novel HMW MAP2 variants with four microtubule-binding repeats and different projection domains
The brain microtubule-associated protein MAP2 is composed of two high molecular (MAP2a and b) and one low molecular (MAP2c) weight isoforms. All these forms were thought to contain three repeated microtubule-binding domains in their C-terminal region but a MAP2c variant containing four repeats has r...
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| Published in: | FEBS letters 1994-11, Vol.354 (3), p.259-262 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4121-c6a6b7c341ea2bb5349f631c361c86bc0c2180090259e4ad9ac0a6ff28ae37c03 |
| container_end_page | 262 |
| container_issue | 3 |
| container_start_page | 259 |
| container_title | FEBS letters |
| container_volume | 354 |
| creator | Langkopf, Anja Guilleminot, Jocelyne Nunez, Jacques |
| description | The brain microtubule-associated protein MAP2 is composed of two high molecular (MAP2a and b) and one low molecular (MAP2c) weight isoforms. All these forms were thought to contain three repeated microtubule-binding domains in their C-terminal region but a MAP2c variant containing four repeats has recently been identified. We report here the existence of two high molecular weight MAP2 isoforms with four microtubule-binding domains in the sensory neuronal cell line ND 7/23. A stretch of 135 bp is missing in one of these forms suggesting that several HMW MAP2 variants can be produced by alternative splicing. |
| doi_str_mv | 10.1016/0014-5793(94)01128-1 |
| format | article |
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A stretch of 135 bp is missing in one of these forms suggesting that several HMW MAP2 variants can be produced by alternative splicing.</description><subject>Alternative Splicing</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Cell Differentiation</subject><subject>Cell Fusion</subject><subject>Cytoskeleton</subject><subject>Genetic Variation</subject><subject>MAP2a/b</subject><subject>Microtubule</subject><subject>Microtubule-Associated Proteins - chemistry</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubules - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Neuroblastoma</subject><subject>Neuron</subject><subject>Neurons - chemistry</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqNUcFu1DAUtBCoLIU_AMknBIdQv9hx4gtSW3UpUqtyaNWj5Tgv4CqxFzvZVf8ep7vqEThZnpk3fp4h5D2wL8BAnjAGoqhqxT8p8ZkBlE0BL8gKmpoXXMjmJVk9S16TNyk9sHxvQB2Ro1otaLUi7e0uUB-2ONDL63t6ffqjpFsTnfFTojs3_aJ9mCMdnY1hmtt5wKJ1vnP-J424QZNVxne0c32PEf1ENzE8oJ1c8LQLo3E-vSWvejMkfHc4j8nd-uL2_LK4uvn2_fz0qrACSiisNLKtLReApmzbigvVSw6WS7CNbC2zJTSMKVZWCoXplLHMyL4vG4O8towfk49737zC7xnTpEeXLA6D8RjmpGvZQF0p8U8hyEWlVBaKvTB_PqWIvd5EN5r4qIHppQO9BKyXKLUS-qkDDXnsw8F_bkfsnocOoWd-ved3bsDH__LU64uzciEWXIkndHno694Ic6xbh1En69Bb7FzMHeguuL9v-gddCakO</recordid><startdate>19941114</startdate><enddate>19941114</enddate><creator>Langkopf, Anja</creator><creator>Guilleminot, Jocelyne</creator><creator>Nunez, Jacques</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941114</creationdate><title>Two novel HMW MAP2 variants with four microtubule-binding repeats and different projection domains</title><author>Langkopf, Anja ; Guilleminot, Jocelyne ; Nunez, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4121-c6a6b7c341ea2bb5349f631c361c86bc0c2180090259e4ad9ac0a6ff28ae37c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alternative Splicing</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Cell Differentiation</topic><topic>Cell Fusion</topic><topic>Cytoskeleton</topic><topic>Genetic Variation</topic><topic>MAP2a/b</topic><topic>Microtubule</topic><topic>Microtubule-Associated Proteins - chemistry</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubules - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Neuroblastoma</topic><topic>Neuron</topic><topic>Neurons - chemistry</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langkopf, Anja</creatorcontrib><creatorcontrib>Guilleminot, Jocelyne</creatorcontrib><creatorcontrib>Nunez, Jacques</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langkopf, Anja</au><au>Guilleminot, Jocelyne</au><au>Nunez, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two novel HMW MAP2 variants with four microtubule-binding repeats and different projection domains</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1994-11-14</date><risdate>1994</risdate><volume>354</volume><issue>3</issue><spage>259</spage><epage>262</epage><pages>259-262</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The brain microtubule-associated protein MAP2 is composed of two high molecular (MAP2a and b) and one low molecular (MAP2c) weight isoforms. 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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1994-11, Vol.354 (3), p.259-262 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76817594 |
| source | Elsevier ScienceDirect Journals |
| subjects | Alternative Splicing Amino Acid Sequence Animals Base Sequence Binding Sites Cell Differentiation Cell Fusion Cytoskeleton Genetic Variation MAP2a/b Microtubule Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - genetics Microtubules - metabolism Molecular Sequence Data Molecular Weight Neuroblastoma Neuron Neurons - chemistry Polymerase Chain Reaction Rats Repetitive Sequences, Nucleic Acid Tumor Cells, Cultured |
| title | Two novel HMW MAP2 variants with four microtubule-binding repeats and different projection domains |
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