Neural control of the forms of acetylcholinesterase in slow mammalian muscles

The ‘heavy’, collagen-tailed form of acetylcholinesterase (AChE), having a s 20,w ° of 16S in mammals, occurs at vertebrate muscle endplates and has been widely regarded as a marker of neuronal influence on muscle in vivo 1–5 . However, an interesting exception has been described by Bacou et al ., i...

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Bibliographic Details
Published in:Nature (London) 1986-05, Vol.321 (6065), p.72-74
Main Authors: Lai, Josephine, Jedrzejczyk, Jolanta, Pizzey, John A, Green, David, Barnard, Eric A
Format: Article
Language:English
Subjects:
Acetylcholinesterase - isolation & purification
Acetylcholinesterase - metabolism
Animals
Biological and medical sciences
Centrifugation, Density Gradient
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Humanities and Social Sciences
Isoenzymes - isolation & purification
Isoenzymes - metabolism
letter
Mammals
Molecular Weight
multidisciplinary
Muscle Denervation
Muscles
Muscles - enzymology
Muscles - innervation
Muscular system
Organ Specificity
Rabbits
Science
Science (multidisciplinary)
Species Specificity
Striated muscle. Tendons
Vertebrates
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:The ‘heavy’, collagen-tailed form of acetylcholinesterase (AChE), having a s 20,w ° of 16S in mammals, occurs at vertebrate muscle endplates and has been widely regarded as a marker of neuronal influence on muscle in vivo 1–5 . However, an interesting exception has been described by Bacou et al ., in a previous report in Nature 6 . They found, in a slow-twitch muscle of the rabbit, that after denervation the 16S form of AChE increases markedly, rather than disappearing. Such a phenomenon would modify current concepts of neuromuscular regulation. We report here, however, that this exception is apparent rather than real in terms of endplate AChE regulation.
ISSN:0028-0836
1476-4687
DOI:10.1038/321072a0