Antimitotic and Cytotoxic Flavonols from Zieridium pseudobtusifolium and Acronychia porteri

Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tub...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-07, Vol.57 (7), p.1012-1016
Main Authors: Lichius, Johannes J, Thoison, Odile, Montagnac, Alain, Païs, Mary, Guéritte-Voegelein, Françoise, Sévenet, Thierry, Cosson, Jean-Pierre, Hadi, Abdul Hamid A
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CYTOTOXIC COMPOUNDS
DRUG PLANTS
Drug Screening Assays, Antitumor
ENFERMEDADES HUMANAS
ESPECTROMETRIA
FEUILLE
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
GLICOPROTEINAS
GLYCOPROTEINE
GLYCOPROTEINS
HOJAS
HUMAN DISEASES
HUMAN NASOPHARYNGEAL CARCINOMA
Humans
INHIBICION
INHIBITION
KB Cells
LEAVES
Magnetic Resonance Spectroscopy
MALADIE DE L'HOMME
MALAISIE
MALASIA
MALAYSIA
Mass Spectrometry
MEDICAMENT CYTOSTATIQUE
MEDICINAL PLANTS
MITOSE
MITOSIS
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
NEW CALEDONIA
NOUVELLE CALEDONIE
NUEVA CALEDONIA
Plant Leaves - chemistry
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants - chemistry
RUTACEAE
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrophotometry, Ultraviolet
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
TUBULIN
Tubulin - metabolism
Tumor Cells, Cultured
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Summary:Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tubulin assembly into microtubules (IC50 12 microM). Two other known flavonols, digicitrin [2] and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone [5], were also isolated together with three new ones, 3-O-demethyldigicitrin [3], 3,5,3'-trihydroxy-6,7,8,4'-tetramethoxyflavone [4], and 3,5-dihydroxy-6,7,8,3',4'-pentamethoxyflavone [6]. All of these flavonols showed cytotoxic activity against KB cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50109a024