Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding

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Bibliographic Details
Published in:Journal of medicinal chemistry 1994-11, Vol.37 (23), p.3863-3866
Main Authors: Dolle, R E, Singh, J, Rinker, J, Hoyer, D, Prasad, C V, Graybill, T L, Salvino, J M, Helaszek, C T, Miller, R E, Ator, M A
Format: Article
Language:English
Subjects:
Amides - chemistry
Amino Acid Sequence
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Aspartic Acid - pharmacology
Caspase 1
Cysteine Endopeptidases - drug effects
Cysteine Endopeptidases - metabolism
Cysteine Proteinase Inhibitors - metabolism
Cysteine Proteinase Inhibitors - pharmacology
Ketones - metabolism
Ketones - pharmacology
Molecular Sequence Data
Nitrogen - chemistry
Structure-Activity Relationship
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ISSN:0022-2623
DOI:10.1021/jm00049a001